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In the 1960s, the advent of the hormone pill for women marked a turning point in the modern era of contraception. Element engine of a revolution of manners, that fertility control does not always male part. Indeed, men have the choice between condoms and vasectomy.
The pill is for the man she myth or a reality next? Periodically, the media echo of ads on a possible placing on the market within five or ten years of a male pill. A lack of commercial interest and the peculiarities of the male reproductive system explain the delay by research in this area. On the one hand, few men still claiming the contraceptive pill, preferring to leave the care to women and on the other hand, the testicles have a dual function sperm production but also the male hormones; the challenge is to be able to stop only the first.
Duality of the male reproductive system
It is more difficult to prevent the production of sperm that ovulation. The woman produces one egg a month, the man 30 million sperm per day. The period of fertility a woman stops at menopause, a man is fertile all his life. But the major difficulty of hormonal contraception is the dual function of the testes. These contain two types of cells intimately linked: Leydig cells and Sertoli cells. The first to the production of testosterone, the main male hormone which is responsible for the appearance of secondary sexual characteristics: hair, driven by voice, muscular male type, etc..
Many more, the Sertoli cells (large pyramidal cells) are used to foster sperm cells. They also protect blood toxic substances germ cells that produce sperm. The maturation of sperm takes place in the tubules and lasts about 74 day in humans. This development includes four phases organized in a spatial and temporal rigorous includes developments in spermatogonia Spermatocyte first and second class and then spermatid. They will mature and stand out in a final step to becoming free of sperm.
Sperm production is controlled by different hormones. Basically, LH (luteinizing hormone or) control the production of testosterone Leydig cell while FSH (or hormone stimulation of follicles) acts directly on the Sertoli cells that play an important role in controlling metabolism and the differentiation of germ cells. Both systems are closely linked because both hormones are stimulated by GnRH gonadolibérine protein that develops in the pituitary gland.
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